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bigscaryd:

rakkiankh:

Even as a zelink shipper whenever people refer to Link and Zelda as soulmates it makes me laugh, cause yeah you’re not wrong they totally are but Ganondorf is also technically their soulmate in that regard? The poly shippers have gotten around that issue but for everyone else he’s literally born to third wheel. No wonder he’s pissed, not only does he never get to realize his ambitions he’s gotta watch that awkward teenage romance over and over for eternity. It’s like he keeps scrolling past his NOTP and the block button isn’t working. Bottling the princess just pisses off the other one, and the other one has the invincibility of a Nokia cell phone. What’s a born hater to do

Bottling the other one just leads to getting bottled by the princess until he wakes up and arrives screaming, half-baked, confused, and angry.

wahoo-shem:

afterword:

idk who needs to hear this rn but suffering is not noble. take the tylenol

One time when I was younger I was refusing to take headache medicine and my mom said “the person who invented that medicine is probably so sad you won’t let them help you” and now every time I find myself denying medicine I just imagine the saddest scientist making those big wet eyes like “why won’t you let me help” and whoop then I take the medicine

rosslynpaladin:

creative-anchorage:

thebibliosphere:

rosslynpaladin:

ultrafacts:

source {x}

*drops phone, staring backward at ancestors* Mother fu-

*stares in multiple autoimmune disorders*

For the study, more than 500 ancient DNA samples were extracted from the remains of individuals, including those buried in London’s East Smithfield plague pits, which were used for mass burials in 1348 and 1349. The samples came from people who had either died before the plague, died from it or survived the Black Death.

Signs of any genetic adaptation related to the plague, which is caused by the bacterium Yersinia pestis, were then looked for. Having two copies of the “good” ERAP2 gene was found to have allowed individuals to produce functional proteins – molecules which help the immune system recognise an infection.

These ERAP2 copies allowed for “more efficient neutralisation of Y pestis by immune cells”, according to the scientists from McMaster University, the University of Chicago, the Pasteur Institute and other organisations.

The presence of the variant would have made a person about 40% more likely to survive the Black Death than those who did not have it.

Hendrik Poinar, professor of anthropology at McMaster University in Canada and co-senior author on the study, said the research was the first study of how pandemics could modify genomes but go undetected in modern populations.

“These genes are underbalancing selection – what provided tremendous protection during hundreds of years of plague epidemics has turned out to be autoimmune-related now,” he added.

“A hyperactive immune system may have been great in the past but in the environment today it might not be as helpful.”

“A hyperactive immune system may have been great in the past but in the environment today it might not be as helpful.”

So I have such a keyed up immune system that it’s got trauma from the BLACK PLAGUE and will now attack even me? SHEESH. (I wish it’d protect me from other viruses and things, Colds take months to get through and then recover from, and nearly hospitalize me. I have to hide from Covid-19)
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